Dr. Darien Sutton discusses the new stem cell treatment and pharmaceutical trial that allows Brian Shelton’s body to control its own insulin and blood sugar levels.
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In the United States, 1 in 10 individuals has diabetes, which affects how the body processes food into energy. One potential therapy is a once-weekly injectable dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide receptor agonist (GLP-1) that aims to control blood sugar. Injected under the skin, GLP-1 and GIP receptors cause the pancreas to release insulin and block the hormone glucagon, limiting blood sugar spikes after a meal. Additionally, it slows digestion, resulting in individuals remaining full longer and eating less. Thus far, late phase III clinical trials reveal that the treatment significantly reduces hemoglobin A1C in type 2 diabetes and supports weight loss, making it potentially the most effective therapy for diabetes and obesity yet developed.
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In this video, we explain what causes diabetes (type 2 diabetes) and what causes high blood sugar. We review how does diabetes start and what is the role of insulin in diabetes. We review the role of the pancreas in diabetes and how does food and weight gain can lead to diabetes. We use the analogy of a steam engine to explain a complex medical topic in a way anybody can understand. Written by Dr. Christopher Palmeiro DO Msc, endocrinology and diabetes specialist, and produced by Doctablet®.
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This animation describes insulin resistance, an underlying cause of type 2 diabetes. It explains the roles of glucose and the hormone insulin in our body. Symptoms of diabetes are reviewed and various health complications that type 2 diabetes can lead to if left untreated.
The Food and Drug Administration has approved a novel dual-targeted treatment for Type 2 diabetes.
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symptoms of Diabetes Mellitus Type 1
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It is important to keep your type 1 diabetes under control. Some treatment options your doctor may prescribe to help you manage it, are explained.
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Diabetes refers to a group of conditions characterized by a high level of blood glucose, commonly referred to as blood sugar. Too much sugar in the blood can cause serious, sometimes life-threatening health problems.
There are two types of chronic diabetic conditions: type 1 diabetes and type 2 diabetes. Pregnant women may acquire a transient form of the disease called “gestational diabetes” which usually resolves after the birth of baby. Pre-diabetes is when the blood sugar level is at the borderline: higher than normal, but lower than in diabetics. Prediabetes may or may not progress to diabetes.
During food digestion, carbohydrates – or carb – break down into glucose which is carried by the bloodstream to various organs of the body. Here, it is either consumed as an energy source – in muscles for example – or is stored for later use in the liver. Insulin is a hormone produced by beta cells of the pancreas and is necessary for glucose intake by target cells. In other words, when insulin is deficient, muscle or liver cells are unable to use or store glucose, and as a result, glucose accumulates in the blood.
In healthy people, beta cells of the pancreas produce insulin; insulin binds to its receptor on target cells and induces glucose intake.
In type 1 diabetes, beta cells of the pancreas are destroyed by the immune system by mistake. The reason why this happens is unclear, but genetic factors are believed to play a major role. Insulin production is reduced; less insulin binds to its receptor on target cells; less glucose is taken into the cells, more glucose stays in the blood. Type 1 is characterized by early onset, symptoms commonly start suddenly and before the age of 20. Type 1 diabetes is normally managed with insulin injection. Type 1 diabetics are therefore “insulin dependent”.
In type 2 diabetes, the pancreas produces enough insulin but something goes wrong either with receptor binding or insulin signaling inside the target cells. The cells are not responsive to insulin and therefore cannot import glucose; glucose stays in the blood. In other words, type 2 diabetics are “insulin resistant”. Here again, genetic factors predispose susceptibility to the disease, but it is believed that lifestyle plays a very important role in type 2. Typically, obesity, inactive lifestyle, and unhealthy diet are associated with higher risk of type 2 diabetes. Type 2 is characterized by adult onset; symptoms usually appear gradually and start after the age of 30. Type 2 diabetes accounts for about 80 to 90% of all diabetics. Management focuses on weight loss and includes a low-carb diet.
What is diabetes mellitus? Diabetes mellitus is when there’s too much glucose, a type of sugar, in the blood. Diabetes mellitus can be split into type 1, type 2, as well as a couple other subtypes, including gestational diabetes and drug-induced diabetes.
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Diabetes experts explain the microvascular (small) and macrovascular (large) vessel complications that can occur in type 2 diabetes.
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Diabetes is diagnosed through laboratory blood tests: the fasting blood glucose test, hemoglobin A1c test, and the oral glucose tolerance test. Serious complications arise with type 2 diabetes, if not diagnosed early, or if inadequately controlled. Regular check-ups and monitoring are stressed, as these can help delay or prevent many diabetes complications.
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Nearly one-third of people with type 1 diabetes will develop kidney disease. If you are between the ages of 18-65 and have type 1 diabetes you can help slow the progression of kidney disease or even stop it. To learn more about Preventing Early Renal Loss, visit perl-study.org, or call the University of Michigan Comprehensive Diabetes Center at (734) 936-8656.
